Antoine Griezmann scored two goals and assisted on another as the Lions picked up three valuable points at home.
The Lions find themselves shorthanded at the back again as D.C. United visits in a critical home match for Orlando.
The Lions came from behind twice and eventually led late but conceded even later to drop two vital points north of the border.
The Lions try to build on Saturday's win over Columbus as they head north to visit Toronto.
The Pride come off the international break with an afternoon tilt at Houston on Sunday.
The Lions take three points from the Crew in a busy week that includes clashes with Toronto and D.C. United.
After losing the lead twice, Orlando City got a late goal from Ivan Angulo to take a vital three points from the Columbus Crew.
The Lions and Crew do battle for the third time this season, with each looking to climb into a better spot in the playoff race.
A loss to San Diego essentially had the Pride Wave-ing goodbye to the playoffs ahead of the international break.
Justin Ellis and the USMNT, Tyrese Spicer's surgery, a Crew preview, and more.
