Adriana's 22nd-minute goal was enough to lift the Pride over Angel City for a crucial three points.
The Pride continue their playoff push with a trip out west to face fellow contenders Angel City FC.
The Pride used two first-half goals to beat the North Carolina Courage, moving up to seventh in the NWSL.
The Orlando Pride return home after a two-week break to face the North Carolina Courage at Exploria Stadium.
The Pride have signed center back Tori Hansen goalkeeper Kaylie Collins to new contracts and sent them on loan to Australia.
The Pride’s current two-game losing streak is a setback, but they can still qualify for the playoffs with a good finish to the season.
Pride goalkeeper Anna Moorhouse got sent off just three minutes into the match as Orlando's struggles in both September and in the Pacific Northwest continued.
The Pride have another chance to jump over the playoff line as they take on OL Reign in Seattle.
There can be no postseason for the Pride unless they completely rewrite the club's late-season history.
The Pride's three-game winning streak came to an end tonight with a home loss to San Diego Wave FC.