Facundo Torres opened the scoring and then broke a 1-1 tie late from the penalty spot as Orlando City beat the Western Conference leaders.
The Lions roared back from 1-0 down and became just the second team to beat the Fire at Soldier Field this season.
A tie score from halftime was broken by yet another soft penalty given to an Orlando opponent and the Lions are done with Leagues Cup.
Wilder Cartagena's stoppage-time goal snapped a 2-2 deadlock and lifted the Lions into the Round of 32.
The Lions conceded a highly questionable penalty at the end of the first half, then battled back to equalize and won the postgame shootout.
Antonio Carlos and Duncan McGuire led the Lions to a comeback victory in Atlanta.
After conceding a pair of goals on first-half set pieces, the Lions never mounted any kind of challenge.
For the second straight year, the Lions dominated Toronto FC at home, winning 4-0.
The Lions made it six in a row at home without a loss with a win over the Fire.
The Lions put in a great effort but it fell a bit short with Mauricio Pereyra missing a gaping net from right in front late in...
Atlanta struggles defensively. They aren't good at set piece defending and the CBs are questionable. If he's healthy, CB Stian…